It does not literally mean the creation of drugs or medical devices that are unique to a patient but rather the ability to classify individuals into subpopulations that differ in their susceptibility to a particular disease or their response to a specific treatment. Preventive or therapeutic interventions can then be concentrated on those who will benefit, sparing expense and side effects for those who will not. [Extracts from President’s Council of Advisors on Science and Technology (PCAST) “Priorities for Personalized Medicine” September 2008]

Genetic Profile

Gene Trek Genomics offers screening for a large number of mutations and SNPs-by offering a comprehensive panel of CLIA, GINA, and HIPAA accredited genomic testing which screens for close to 100 potential medical conditions, such as Breast Cancer, Prostate Cancer, Alzheimer Disease, Cardiovascular diseases, Rheumatoid Arthritis, Type 1 and 2 Diabetes, and many more, for an affordable low price. We scan your DNA for thousands of genetic markers that indicate your risk for adverse health conditions. Some of the markers have been researched more thoroughly than others, but scientific knowledge advances rapidly. While we provide a thorough risk assessment based on the science that is currently available, more tests are always just over the horizon. After your DNA is tested, you will have the option of having your DNA sample secured and stored Just in case to be re-tested down the road as new science emerges. As new prevention measures, drug reactions (positive or adverse) and risks based on your specific genes are scientifically validated, you'll be the first to know!

ONLY YOU HAVE ACCESS TO YOUR GENETIC PROFILE, NOT THE INSURANCE COMPANIES

Genomic Testing

For Autosomal Dominant disorders, an affected individual carries one copy of a gene mutation for the related condition, while for Autosomal Recessive disorder the affected person has two copies of the mutation, and a carrier person who can be asymptomatic (unaffected) has one normal gene and one mutated gene for related disorder. When both parents are carriers for a mutated gene, their chance of having an affected child carrying both mutated gene (one from each parent) is 25%. Testing both parents therefore can provide information about their risk of having a child with tested genetic conditions specially, if you have a family history of a genetic disorder or your ethnic background indicates an increased risk for specific genetic conditions. In X-linked disorders, the mutated gene for a condition is on the X-chromosome. Females have two X-chromosomes and males have an X- and a Y-chromosome. Therefore, a female carrying one copy of mutation will be a carrier for the related condition (majority asymptomatic), while a male carrying one copy of the mutation will be affected, because he does not have a normal copy of the related gene on his Y chromosome. Complex Multi-factorial Disorders require a combination of genetic and environmental factors to trigger the disease.

Conditions Tested (As of January 2010)

New discoveries occur rapidly in the area of human genetics. Our scientists monitor and carefully evaluate new information published in scientific journals and add new disease-associated variants to our tests as appropriate.

Drug Response

We also test for drug responses and adverse reactions. We screen for drug metabolism enzymes and transporters that have been linked to harmful reactions with common medical prescriptions, empowering you and your doctor with information that could possibly save your life. Research indicates that there are 106,000 deaths and 2.2 Million serious events caused by adverse drug reactions in the US each year. These drug reactions are responsible for 5-7% of hospital admissions in the US and Europe. Here are examples:

Clopidogrel (Plavix): Researchers have found that patients with variations in a gene called cytochrome P-450 2C19 (CYP2C19) have a greater risk for major adverse cardiovascular events such as death, heart attack, and stroke. Warfarin: Every day millions of people take warfarin or Coumadin, a powerful drug used to control life threatening conditions. According to the FDA, hemorrhage during warfarin therapy is a leading cause of death in Western countries and related adverse events account for 1 in 10 hospital admissions.

Tamoxifen: Tamoxifen is a medication for the treatment of breast cancer or for people at a high risk of developing breast cancer. Recent research has shown that 7-10% of women with breast cancer may not receive the full medical benefit from taking tamoxifen due to their unique genetic make-up. These women have a version of a gene called Cytochrome P450 2D6, which reduces the effectiveness of tamoxifen and increases their chance of breast cancer recurrence.

Drugs Tested (As of January 2010)

• Abacavir Hypersensitivity
• Caffeine Metabolism
• Carbamazepine Hypersensitivity
• Clopidrogel Metabolism
• Methotrexate Toxicity
• Statin Induced Myopathy
• Statin protection against myocardial infarction
• Tamoxifen Response
• Warfarin Metabolism

How To Order Test

	Order a test onlinehereor call us at 877-436-8735 to receive the Specimen Collection Kit.
	Collect your Saliva in a Container we send you
	Mail the Sample to the Lab
	DNA is Processed and Analyzed
	Access your Results on Customer’s Secure On-line Account